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KMID : 0358320140550040239
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Korean Journal of Urology
2014 Volume.55 No. 4 p.239 ~ p.244
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Relating Prognosis in Chromophobe Renal Cell Carcinoma to the Chromophobe Tumor Grading System
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Weinzierl Elizabeth P
Thong Alan E
McKenney Jesse K
Jeon Seung-Hyun
Chung Benjamin I
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Abstract
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Purpose: The chromophobe subtype of renal cell carcinoma (chRCC) has generally been associated with a better prognosis than the clear cell type; however, debate continues as to absolute prognosis as well as the significance of certain prognostic variables. We investigated the significance of pathologic stage and a recently proposed chromophobe tumor grading (CTG) scheme in predicting chRCC outcomes.
Materials and Methods: All available chRCCs were identified from our surgical pathology archives from 1987-2010. Original slides were reviewed to verify diagnoses and stage, and each case was graded following a novel chromophobe tumor grade system criteria. Disease status was obtained from a clinical outcome database, and cancer specific deaths and recurrences were recorded.
Results: Eighty-one cases of chRCC were identified, and 73 had adequate follow-up information available. There were only 3 instances of cancer related recurrence or mortality, which included 1 disease specific mortality and 2 disease recurrences. Pathologic stage and CTG 3 were found to be significantly associated with the recurrences or death from chRCC, but there was no association with CTG 1 and CTG 2.
Conclusions: chRCC is associated with a very low rate of cancer specific events (4.1%) even at a tertiary referral center. In our study, pathologic stage and CTG 3, but not CTG 1 or 2, were significantly associated with the development of these events.
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KEYWORD
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Nephrectomy, Prognosis, Renal cell carcinoma
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